姓名： 刘甲野

性别： 男

最高学位： 博士

职称： 研究员

工作单位： 长治医学院

电子邮件： liujiaye1984@163.com

导师类型： 硕士生导师

专业学位领域： 105300公共卫生

研究方向：疾病预防控制

简介：

刘甲野，医学博士，副教授，特聘研究员，深圳市高层次人才。研究方向：HIV感染者免疫功能重建、低病毒血症和非艾滋相关疾病干预、慢乙肝抗病毒治疗策略优化、疫苗可预防传染病免疫策略、重大传染病循证医学、临床试验及真实世界研究设计与数据处理等。承担预防医学本科生、硕士研究生教学工作，指导硕士研究生10余名。近年主持国家和省市级课题10余项，以第一作者或通讯作者在Lancet子刊、Hepatology、Infectious Diseases of Poverty、Emerging Infectious Diseases、Emerging Microbes & Infections、Journal of Infection、The Journal of Infectious Disease等期刊发表科研论文40余篇，他引2000余次，其中高被引论文2篇。获山东省科技进步二等奖和山东省医学科技创新奖。担任《中国艾滋病性病》、《中华肿瘤防治杂志》等期刊编委。

代表性科研项目：

1. 基于聊天机器人对HIV感染者心血管疾病发病风险进行精准干预的模式探索及效果评价，国家自然科学基金面上项目，2025.

2. 艾滋病儿童人群综合诊治新策略研究，国家科技重大专项子任务，2025.

3. 基于全国多中心HIV感染者队列的免疫重建不良风险评估模型构建及机制研究，广东省自然科学基金面上项目，2024.

4. 基于多维度认知功能测试的HIV相关神经认知障碍评估与干预效果评价，广东省省医学科研基金项目，2025.

5. 基于大规模双向队列HIV感染人群的心血管疾病风险评分系统构建及其发病机制研究，深圳市科技创新委员会面上项目，2022.

代表性学术成果：

1. Li X, Sun L, He Y, Zhao F, Luo Y, Zhao D, Wu H, He J, Jiang Y, Liu C, Lu H*, Liu J*. Two-threshold defined immune non-responders are associated with long-term morbidity in people with HIV: a prospective cohort study. Emerg Microbes Infect. 2025 Dec;14(1):2539198.

2. Luo Y^, Sun L^, He Y, Zhao F, Shan D, Bu F, Ge L, Li X, Hu Y, Xiao X, Lu H*, Liu J*. The triglyceride-glucose index trajectories are associated with cardiovascular diseases in people living with HIV: evidence from a prospective cohort study in China, 2005-2022. BMC Public Health. 2025; 25:465.

3. Jiang Y^, Luo Y^, Xiao X^, Li X, Hu Y, Liu C, Zhao D, Kong T, Liu J*. Global, regional, and national burdens of vaccine-preventable infectious diseases with high incidence among middle-aged and older adults aged 55-89 years from 1990 to 2021: Results from the global burden of disease study 2021. Vaccine. 2025; 49:126786.

4. Sun L^, Luo Y^,, Jia X^,, Wang H, Zhao F, Zhang L, Ju B, Wang H, Shan D, He Y, Lu H*, Liu J*. Association between the triglyceride to high-density lipoprotein cholesterol ratio and cardiovascular diseases in people living with human immunodeficiency virus: Evidence from a retrospectively cohort study 2005-2022. Chin Med J (Engl). 2024; 137:2712-2719.

5. Ge L^, Luo Y^, Li X^, Hu Y, Sun L, Bu F, Shan D, Liu J*. Global, regional, and national prevalence of HIV-1 drug resistance in treatment-naive and treatment-experienced children and adolescents: a systematic review and meta-analysis. EClinicalMedicine. 2024 4; 77:102859.

6. Lv J^, Wu H^, Xu J, Liu J*. Immunogenicity and safety of heterologous versus homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine: a systematic review. Infect Dis Poverty. 2022, 11(1):53.

7. Li T, Zhao Y, Yuan L, Zhang D, Feng Y, Hu H, Hu D, Liu J*. Total dietary flavonoid intake and risk of cardiometabolic diseases: A dose-response meta-analysis of prospective cohort studies. Crit Rev Food Sci Nutr. 2022 Sep 23:1-13.

8. Hou Y^, Liu J^, Zhao Y^, Wu Y, Ma Y, Zhao D, Dou Z, Liu Z, Shi M, Jiao Y, Huang H, Wu Z, Wang L*, Han M*, Wang FS*. Epidemiological trends of severely immunosuppressed people living with HIV at time of starting antiretroviral treatment in China during 2005-2018. J Infect. 2022 Mar;84(3):400-409.

9. Liu J*, Li T, Zhang L, Xu A. The role of hepatitis B surface antigen in nucleos(t)ide analogues cessation among asian chronic hepatitis B patients: a systematic review. Hepatology, 2019, 70:1045-1055.

10. Liu J^, Liao X^, Qian S, Yuan J, Wang F, Liu Y, Wang Z, Wang F, Liu L*, Zhang Z*. Community Transmission of Severe Acute Respiratory Syndrome Coronavirus 2, Shenzhen, China, 2020. Emerg Infect Dis, 2020, 26: 1320-1323.

11. Liu J^, Wang L^, Hou Y^, Zhao Y^, Dou Z, Ma Y, Zhang D, Wu Y, Zhao D, Liu Z, Zhang F, Jin L, Zhang J, Xu, Shi M, Huang L, Wu Z, Han M*, Gao F*, Wang F*. Immune restoration in HIV-1-infected patients after 12 years of antiretroviral therapy: a real-world observational study. Emerging Microbes & Infections, 2020, 9:2550-2561.

12. Liu J^, Hou Y^, Sun L^, Wang L, He Y, Zhou Y, Xu L, Liu X, Zhao F, Zhang L, Wang H*, Wang F*. High population-attributable fractions of traditional risk factors for non-AIDS-defining diseases among people living with HIV in China: a cohort study. Emerging Microbes & Infections, 2021, 10:416-423.

13. Liu J^, Wang T^, Zhang W^, Cheng Y, He Q, Wang F*. Effect of combination treatment based on interferon and nucleos(t)ide analogues on functional cure of chronic hepatitis B: a systematic review and meta-analysis. Hepatology international, 2020, 14(6):958-972.