谭 铮  教授

谭 铮，理学博士，教授。

邮箱：z.tan@ioz.ac.cn

研究领域：

核酸G-四链体结构与功能

       代表性科研项目：

1. 2000-2005年，国家重点基础研究发展规划(973)项目：衰老机理及老年疾病防治的基础研究：细胞复制性衰老中衰老相关基因、端粒 与端粒酶变化的分子机理，课题组长

2. 2007-2012年，国家重点基础研究发展规划(973)项目：衰老的机制与干预的基础研究：端粒与线粒体在细胞衰老进程的中心作用机制，课题组长

3. 2013-2017年，国家重点基础研究发展规划(973)项目：内脏器官衰老与相关老年疾病防治的基础研究：遗传程序调控器官衰老发生发展的共同机制研究，课题组长

4. 2009-2012年，国家自然科学基金重大研究计划重点项目：化学小分子探针对染色体端粒DNA结构、生物学活性及相关信号转导的干预和影响，子课题负责人

5. 2015-2019，国家自然科学基金重大研究计划重点项目：小分子与核酸的相互识别和调控作用，子课题负责人

       代表性论著：

1. Ren, C.X., Duan, R.F., Wang, J., Hao, Y.H. and Tan, Z*. (2024) Dominant and genome-wide formation of DNA:RNA hybrid G-quadruplexes in living yeast cells. Proc. Natl. Acad. Sci. USA, 121, e2401099121.

2. Jia-yuan Gong, C.-j.W., Ming-liang Tang, Rui-fang Duan, Jia-yu Zhang, Ke-wei Zheng, Yi-de He, Yu-hua Hao, Zheng Tan*. (2021) G-Quadruplex Structural Variations in Human Genome Associated with Single Nucleotide Variations and Their Impact on Gene Activity. Proc. Natl. Acad. Sci. USA, 118(21):e2013230118.

3. Zheng, K.W., Zhang, J.Y., He, Y.D., Gong, J.Y., Wen, C.J., Chen, J.N., Hao, Y.H., Zhao, Y. and Tan, Z.* (2020) Detection of genomic G-quadruplexes in living cells using a small artificial protein. Nucleic Acids Res., 48, 11706-11720.

4. Zheng, K.W., Liu, C., Meng, Q., Hao, Y.H., Zheng, J.P., Li, W. and Tan, Z.* (2020) One-Step High-Throughput Telomerase Activity Measurement of Cell Populations, Single Cells, and Single-Enzyme Complexes. ACS Omega, 5, 24666-24673.

5. Zhang, J.Y., Xia, Y., Hao, Y.H. and Tan, Z.* (2020) DNA:RNA hybrid G-quadruplex formation upstream of transcription start site. Sci Rep, 10, 7429.

6. Wen, C.J., Gong, J.Y., Zheng, K.W., He, Y.D., Zhang, J.Y., Hao, Y.H. and Tan, Z.* (2020) Targeting nucleic acids with a G-triplex-to-G-quadruplex transformation and stabilization using a peptide-PNA G-tract conjugate. Chem. Commun. (Camb.), 56, 6567-6570.

7. Tan, Z., Hao, Y.H. and Zheng, K.W. (2020) Kinetics, conformation, stability, and targeting of G-quadruplexes from a physiological perspective. Biochem. Biophys. Res. Commun., 531, 84-87.

8. He, Y.D., Zheng, K.W., Wen, C.J., Li, X.M., Gong, J.Y., Hao, Y.H., Zhao, Y. and Tan, Z.* (2020) Selective Targeting of Guanine-Vacancy-Bearing G-Quadruplexes by G-Quartet Complementation and Stabilization with a Guanine-Peptide Conjugate. J. Am. Chem. Soc., 142, 11394-11403.

9.  Wen, C.J., Gong, J.Y., Zheng, K.W., He, Y.D., Zhang, J.Y., Hao, Y.H. and Tan Z.* (2020) Targeting nucleic acids with a G-triplex-to-G-Quadruplex transformation and stabilization using a peptide-PNA G-tract conjugate. Chem. Commun. (Camb.). 56, 6567-6570.